{"id":228,"date":"2024-05-13T05:45:46","date_gmt":"2024-05-13T05:45:46","guid":{"rendered":"https:\/\/rockstartesting.in\/quantum\/?page_id=228"},"modified":"2024-08-16T11:02:55","modified_gmt":"2024-08-16T11:02:55","slug":"nanorobotics","status":"publish","type":"page","link":"https:\/\/www.cense.iisc.ac.in\/ambarish\/nanorobotics\/","title":{"rendered":"Nanorobotics"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"228\" class=\"elementor elementor-228\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3c020e87 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3c020e87\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_bottom&quot;:&quot;arrow&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 700 10\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M350,10L340,0h20L350,10z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1181cd5d\" data-id=\"1181cd5d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e603b08 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e603b08\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;background_motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateX_effect&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateX_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:5,&quot;sizes&quot;:[]},&quot;background_motion_fx_translateX_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;background_motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1af2eea8 elementor-invisible\" data-id=\"1af2eea8\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;zoomInLeft&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e622d9b elementor-widget elementor-widget-image\" data-id=\"e622d9b\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"169\" src=\"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-content\/uploads\/2024\/08\/ag-res-nr-1-300x169-1.jpg\" class=\"attachment-full size-full wp-image-661\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-7f35c2c elementor-invisible\" data-id=\"7f35c2c\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;zoomInRight&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2432de33 elementor-widget elementor-widget-elementskit-heading\" data-id=\"2432de33\" data-element_type=\"widget\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_left   ekit_heading_tablet-text_center   ekit_heading_mobile-\"><h4 class=\"elementskit-section-subtitle  \">\n\t\t\t\t\t\tNanorobotics\n\t\t\t\t\t<\/h4><h2 class=\"ekit-heading--title elementskit-section-title \">Studying and engineering collective motion at the nanoscale in <span><span>(bio)-fluidic environments<\/span><\/span><\/h2><div class=\"ekit_heading_separetor_wraper ekit_heading_elementskit-border-divider ekit-dotted\"><div class=\"elementskit-border-divider ekit-dotted\"><\/div><\/div><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3efeecb elementor-widget elementor-widget-ucaddon_ue_unfold\" data-id=\"3efeecb\" data-element_type=\"widget\" data-widget_type=\"ucaddon_ue_unfold.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<!-- start Unfold Content -->\n\t\t<link id='font-awesome-css' href='https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome5\/css\/fontawesome-all.min.css' type='text\/css' rel='stylesheet' >\n\t\t<link id='font-awesome-4-shim-css' href='https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-content\/plugins\/unlimited-elements-for-elementor-premium\/assets_libraries\/font-awesome5\/css\/fontawesome-v4-shims.css' type='text\/css' rel='stylesheet' >\n\n\t\t\t<style type=\"text\/css\">\/* widget: Unfold Content *\/\n\n#uc_ue_unfold_elementor_3efeecb{\n opacity: 0;\n transition: opacity .2s;\n}\n\n#uc_ue_unfold_elementor_3efeecb.ue-full-opacity{\n opacity: 1;\n}\n\n#uc_ue_unfold_elementor_3efeecb .unfold_wrapper{\n  max-height:100%;\n  width: 100%;\n}\n\n#uc_ue_unfold_elementor_3efeecb .unfold_card\n{\n  position: relative;\n  overflow:hidden;\n}\n\n#uc_ue_unfold_elementor_3efeecb .uf_overlayuc_ue_unfold_elementor_3efeecb{\n    position: absolute;\n    right: 0;\n    bottom: 0;\n    left: 0;\n    z-index: 1;\n    background: -moz-linear-gradient(0deg, #ffffff) 10%, rgba(255, 255, 255, 0) 100%);\n    background: -webkit-linear-gradient(0deg, #ffffff 10%, rgba(255, 255, 255, 0) 100%);\n    background: linear-gradient(0deg, #ffffff 10%, rgba(255, 255, 255, 0) 100%);\n}\n\n#uc_ue_unfold_elementor_3efeecb .ue-btn-wrap{\n        display: flex;   \n    position:relative;\n  z-index:2;\n}\n\n#uc_ue_unfold_elementor_3efeecb #button_uc_ue_unfold_elementor_3efeecb{\n    display: flex;\n    justify-content: center;\n    align-items: center;\n    cursor:pointer;\n    transition:0.3s;\n}\n\n.ue-btn-icon\n{\n  line-height:1em;\n}\n\n.ue-btn-icon svg\n{\n  height:1em;\n  width:1em;\n}\n\n#uc_ue_unfold_elementor_3efeecb .unfold_wrapper\n{\n  overflow:hidden;\n  transition:300ms;\n}\n\n#uf_overlayuc_ue_unfold_elementor_3efeecb\n{\n  transition:300ms;\n}\n\n#uc_ue_unfold_elementor_3efeecb .unfold_wrapper.ue-unfold-active #uf_overlayuc_ue_unfold_elementor_3efeecb\n{\n  height:0px;\n}\n\n#ue-icon-unfolded-uc_ue_unfold_elementor_3efeecb\n{\n  display:none;\n}\n\n#ue-text-unfolded-uc_ue_unfold_elementor_3efeecb\n{\n  display:none;\n}\n\n#uc_ue_unfold_elementor_3efeecb  button\n{\n  outline:none;\n}\n\n<\/style>\n\n\t\t\t<div id=\"uc_ue_unfold_elementor_3efeecb\" data-scroll-back=\"true\">\n<div class=\"unfold_card\">\n  <div class=\"unfold_wrapper\" id=\"unfold_wrapper_uc_ue_unfold_elementor_3efeecb\">\n    <div class=\"uf_overlayuc_ue_unfold_elementor_3efeecb uf_overlay\" id=\"uf_overlayuc_ue_unfold_elementor_3efeecb\"><\/div>\n                    <div class=\"ue-txt\"><p>We have developed of a versatile system of motile colloids, which is of current fundamental (active matter, soft matter physics) and technological (microfluidics, biophysics, drug delivery) interest. The experimental system is based on helical magnetic nanostructures (\/nanoswimmers) dispersed in fluidic environments, maneuvered by rotating\/oscillating magnetic fields. Our group has made important contributions in understanding and expanding the scope of this powerful nano-system, and this research has also led to a start-up in the field of medical nanodevices.<\/p><p>We carried out detailed experimental study of the dynamics of the nanoswimmers, performed numerical simulations, and derived analytical formulae that explain the picture accurately. Crucially, this has led to a technology to measure mechanical properties (viscosity) of complex (e.g. shear thinning) and heterogeneous fluidic environments with sub-micron spatial resolution and high speed. In collaboration with biologists, we investigated the toxicity of the swimmers, integrated therapeutic potential, and engineered the system to be suitable for in vivo applications. The start-up from our group builds upon the therapeutic potential of the swimmers in domain of dentistry and will soon be extended to cancer therapeutics. The swimmers could be rendered self-propelled under appropriate magnetic drive, which has resulted in the development of a novel artificial active matter system. We demonstrated the structures can be maneuvered inside living cells with exquisite spatial control, where intracellular manipulation had zero adverse effect on cellular viability, but instead the motion was a strong function of the mechanical microenvironment inside the cell.<\/p><p>A major aim in our immediate future is to demonstrate therapeutic potential of magnetic nanoswimmers under in vivo conditions (in mice), with specific goals in the areas of dentistry and cancer therapy. In this regard, we have recently devised a new strategy toward targeting cancer cells in tissue-like environments under\u00a0<em>ex vivo<\/em>\u00a0conditions. These efforts are on their way to be tried in live mice, and within next few years we hope to complete some of the regulatory questions related with this new therapeutic system: long and short-term toxicity, bio-distribution, deep tissue imaging etc. These highly applied efforts will be complemented with fundamental studies of their collective dynamics and swarm behavior, especially how to engineer a collection of motile \u201cfantastic voyagers\u201d to achieve the envisioned tasks. Our dream is to reach clinical trials with this novel therapeutic strategy within the next few years. On a parallel effort we are pursuing right now, the swimmers have been integrated with quantum sensing (N-V centers) properties, which offer a unique probe as sensing and perturbing agents in biophysical processes (both intracellular and extracellular), in a spatiotemporal scale that has never been studied. Development of this unique toolbox for biophysical studies will be another one of our major goals over next five years.<\/p><\/div>\n        <\/div>\n    <div class=\"ue-btn-wrap\" id=\"btn_wrapper btn_wrapper_uc_ue_unfold_elementor_3efeecb\"> \n     <div class=\"ubfold_btn\" id=\"button_uc_ue_unfold_elementor_3efeecb\">\n                  <span class=\"ue-btn-icon\" id=\"ue-icon-folded-uc_ue_unfold_elementor_3efeecb\"><i class='fas fa-angle-down'><\/i><\/span>\n          <span class=\"ue-btn-icon\" id=\"ue-icon-unfolded-uc_ue_unfold_elementor_3efeecb\"><i class='fas fa-angle-up'><\/i><\/span>\n                 <span id=\"ue-text-folded-uc_ue_unfold_elementor_3efeecb\">Read More<\/span>\n        <span id=\"ue-text-unfolded-uc_ue_unfold_elementor_3efeecb\">Read Less<\/span>\n     <\/div>\n   <\/div>\n\t\n<\/div>\n\n<\/div>\n\t\t\t<!-- end Unfold Content -->\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1548e1be elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1548e1be\" data-element_type=\"section\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48404f91\" data-id=\"48404f91\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7931f06b elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"7931f06b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInDown&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-32283d0\" data-id=\"32283d0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-668087f elementor-widget elementor-widget-video\" data-id=\"668087f\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=sYq1LrPVY8g&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-video .elementor-widget-container{overflow:hidden;transform:translateZ(0)}.elementor-widget-video .elementor-wrapper{aspect-ratio:var(--video-aspect-ratio)}.elementor-widget-video .elementor-wrapper iframe,.elementor-widget-video .elementor-wrapper video{height:100%;width:100%;display:flex;border:none;background-color:#000}@supports not (aspect-ratio:1\/1){.elementor-widget-video .elementor-wrapper{position:relative;overflow:hidden;height:0;padding-bottom:calc(100% \/ var(--video-aspect-ratio))}.elementor-widget-video .elementor-wrapper iframe,.elementor-widget-video .elementor-wrapper video{position:absolute;top:0;right:0;bottom:0;left:0}}.elementor-widget-video .elementor-open-inline .elementor-custom-embed-image-overlay{position:absolute;top:0;right:0;bottom:0;left:0;background-size:cover;background-position:50%}.elementor-widget-video .elementor-custom-embed-image-overlay{cursor:pointer;text-align:center}.elementor-widget-video .elementor-custom-embed-image-overlay:hover .elementor-custom-embed-play i{opacity:1}.elementor-widget-video .elementor-custom-embed-image-overlay img{display:block;width:100%;aspect-ratio:var(--video-aspect-ratio);-o-object-fit:cover;object-fit:cover;-o-object-position:center center;object-position:center center}@supports not (aspect-ratio:1\/1){.elementor-widget-video .elementor-custom-embed-image-overlay{position:relative;overflow:hidden;height:0;padding-bottom:calc(100% \/ var(--video-aspect-ratio))}.elementor-widget-video .elementor-custom-embed-image-overlay img{position:absolute;top:0;right:0;bottom:0;left:0}}.elementor-widget-video .e-hosted-video .elementor-video{-o-object-fit:cover;object-fit:cover}.e-con-inner>.elementor-widget-video,.e-con>.elementor-widget-video{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Nanorobotics Studying and engineering collective motion at the nanoscale in (bio)-fluidic environments We have developed of a versatile system of motile colloids, which is of current fundamental (active matter, soft matter physics) and technological (microfluidics, biophysics, drug delivery) interest. The experimental system is based on helical magnetic nanostructures (\/nanoswimmers) dispersed in fluidic environments, maneuvered by&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-228","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/pages\/228"}],"collection":[{"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/comments?post=228"}],"version-history":[{"count":15,"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/pages\/228\/revisions"}],"predecessor-version":[{"id":664,"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/pages\/228\/revisions\/664"}],"wp:attachment":[{"href":"https:\/\/www.cense.iisc.ac.in\/ambarish\/wp-json\/wp\/v2\/media?parent=228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}