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DTSTART;TZID=Asia/Kolkata:20260904T160000
DTEND;TZID=Asia/Kolkata:20260904T170000
DTSTAMP:20260904T060010Z
CREATED:20260904T055520Z
LAST-MODIFIED:20260904T060010Z
UID:10817-1788537600-1788541200@www.cense.iisc.ac.in
SUMMARY:[Thesis Colloquium] : From Molecular Detection to Single-Cell Sequencing: Engineering Biological Information for Nanopore Readout
DESCRIPTION:Thesis Title :  "From Molecular Detection to Single-Cell Sequencing: Engineering Biological Information for Nanopore Readout"\n\nName of the Student : Mr. Mayank Mitram\n\nDegree Registered : Ph.D. Engineering \n\nAdvisor : Prof. Manoj Varma\, CeNSE\n\nDate : 4th September 2026 (Friday)\n\nTime : 4:00 PM\n\nVenue : CeNSE Seminar Hall (Hybrid)\nAbstract:\n\nBiological systems contain information across multiple scales\, from individual biomolecules to \nheterogeneous populations of cells. However\, conventional analytical approaches often require \ndifferent measurement strategies for different molecular classes and may obscure cell-to-cell \nheterogeneity. This thesis has focused on developing sequencing-enabled strategies to convert \ndiverse forms of biological information into interpretable\, nucleic-acid-based readouts\, with an \nemphasis on Oxford Nanopore sequencing.\n\nThe first part of this work establishes a PCR-free platform for Multiplexed detection of proteins\, \nmicroRNAs\, and small biomolecules by integrating molecular recognition\, Hybridization Chain Reaction \n(HCR)\, and DNA barcoding with nanopore sequencing. In this approach\, target recognition initiates the \nformation of sequence-defined DNA products containing target-specific barcodes\, thereby translating the \npresence of chemically diverse analytes into a common sequencing-readable format. The platform enables\nmultiplexed detection with minimal cross-reactivity and was further investigated in increasingly complex \nbiological backgrounds\, demonstrating the potential of nanopore sequencing as a unified readout for \nheterogeneous molecular targets.\n\nWhile molecular encoding provides information about what is present\, biological heterogeneity also requires \nknowledge of where that information originates. This motivates the second part of the thesis\, in which a \nMicrofabricated PDMS hydrophobic-barrier platform for bacterial single-cell capture is developed. The device \nincorporates patterned hydrophobic barriers and hydrophilic capture regions to generate spatially isolated \nmicroenvironments\, enabling parallel isolation of individual bacterial cells while preserving their spatial \nidentity. Microfabrication and surface characterization demonstrated the formation of well-defined structures \nsuitable for high-density single-cell capture.\n\nBuilding upon this platform\, the third part of the thesis explores Bacterial single-cell sequencing using \nOxford Nanopore technology. A workflow was developed to process individually captured bacterial cells for \nmolecular recovery and sequencing\, addressing challenges associated with bacterial RNA\, including the absence \nof conventional poly(A) tails and the high abundance of ribosomal RNA. The resulting approach provides a route \ntoward cell-resolved molecular characterization using nanopore sequencing.\n\nTogether\, these studies represent a progression from molecular detection to spatially resolved single-cell analysis\, \nunified by a common principle: Engineering biological information into formats that can be read by sequencing. \nThis work establishes a foundation for future platforms capable of integrating multiplexed molecular detection \nwith single-cell resolution to interrogate biological systems across multiple scales.
URL:https://www.cense.iisc.ac.in/event/thesis-colloquium-from-molecular-detection-to-single-cell-sequencing-engineering-biological-information-for-nanopore-readout/
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DTSTART;TZID=Asia/Kolkata:20260923T160000
DTEND;TZID=Asia/Kolkata:20260923T170000
DTSTAMP:20260904T061213Z
CREATED:20260904T060744Z
LAST-MODIFIED:20260904T061213Z
UID:10824-1790179200-1790182800@www.cense.iisc.ac.in
SUMMARY:[Seminar] : Engineering Dielectric Interfaces in Nanoscale Transistors
DESCRIPTION:Speaker: Prof. Dipanjan Sen\, Postdoctoral Associate\, Research Laboratory of Electronics (RLE)\, Massachusetts Institute of Technology (MIT).\n\nTitle: "Engineering Dielectric Interfaces in Nanoscale Transistors"\n\nDate: Wednesday\, 23rd September 2026 - Time: 4 PM\n\nHi-Tea & Coffee: 5 PM\n\nVenue: CeNSE Seminar Hall\n\nAbstract:\n\nAs scaling enters the Ångström era\, the frontier is shifting from the semiconductor channel toward \nthe dielectric and its interfaces. In atomically thin systems\, channel-dielectric coupling becomes \nstrong enough to define device behavior. This talk shows how that coupling in 2D heterostructures \nenables cryogenic non-volatile ferroelectric memory\, programmable threshold-voltage engineering for \nlow-power 2D CMOS\, solid-state iontronic thermometry\, and neuromorphic photon–ion–electron-coupled devices. \nExtending the same philosophy to mainstream CMOS scaling\, ultrathin ALD-grown HfO2–ZrO2 gate stacks \nengineered near the atomic limit enhance gate capacitance and scale equivalent oxide thickness beyond \nconventional interfacial-layer limits\, while preserving transport\, leakage\, and reliability. \nDielectrics thus emerge as active materials\, motivating a forward-looking program on atomically \nengineered gate stacks for CMOS and beyond-CMOS devices.\n\nBiography:\n\nDipanjan Sen is a Postdoctoral Associate in the Research Laboratory of Electronics (RLE) at \nthe Massachusetts Institute of Technology\, where he works with Prof. Suraj Cheema on gate-stack \nengineering for CMOS and beyond CMOS devices. His current research focuses on extreme EOT scaling \nthrough ultrathin\, ALD-grown gate stacks and their integration into foundry-relevant platforms. \nHe earned his PhD at the Pennsylvania State University in the group of Prof. Saptarshi Das\, where \nhis work on 2D-material/dielectric interfaces produced a broad family of emerging devices spanning \ncryogenic ferroelectric memory\, threshold-voltage engineering for 2D CMOS\, iontronic sensing\, and \nneuromorphic computing\, with results appearing in journals including Nature Electronics\, Nature \nCommunications\, Nature Sensors\, ACS nano etc. Across his work\, Dipanjan is driven by a single \nquestion- how the engineering of dielectric interfaces\, atom by atom\, can unlock new functionality \nand extend the limits of the modern transistor.\n\nHost Faculty:  Prof. Manoj Varma
URL:https://www.cense.iisc.ac.in/event/seminar-engineering-dielectric-interfaces-in-nanoscale-transistors/
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DTSTART;TZID=Asia/Kolkata:20260925T160000
DTEND;TZID=Asia/Kolkata:20260925T170000
DTSTAMP:20260922T050201Z
CREATED:20260922T045806Z
LAST-MODIFIED:20260922T050201Z
UID:10897-1790352000-1790355600@www.cense.iisc.ac.in
SUMMARY:[Seminar] : Manipulating Light Flow at Chip Scale
DESCRIPTION:Speaker: Prof. Shankar Kumar Selvaraja\, CeNSE\, IISc.\n\nTitle: "Manipulating Light Flow at Chip Scale"\n\nDate: Friday\, 25th September 2026 - Time: 4 PM\n\nVenue: CeNSE Seminar Hall\n\nAbstract:\n\nIn this talk\, I will cover the exciting world of chip-scale light propagation and control. \nThe control enables useful application in communication\, computing and sensing. \nThe presentation will cover based concept and some state-of-the-art demonstrations from our lab. \n\nBiography:\n\nProfessor Shankar Kumar Selvaraja is Associate Chair at the CeNSE\, IISc Bangalore\, \nand Project Director of the Quantum Computing Thematic Hub under India’s National Quantum Mission. \nBefore IISc\, he worked at imec Belgium on wafer‑scale silicon photonic for optical interconnect \napplications. He is an alumnus of University of Twente the Netherlands\, College of Engineering\, \nGundy\, Anna University and Bharathiar University. He has over 300 publications\, more than a dozen patents. \nHis research area includes photonic IC technology for compute\, communication and sensing application. \n\nHost Faculty:  Prof. Vini Gautam
URL:https://www.cense.iisc.ac.in/event/seminar-manipulating-light-flow-at-chip-scale/
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