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Manoj Varma

Research Interests

  • Noise in biochemical sensing
  • Biosensors
  • Autonomous robots


  • Harish Sasikumar, Manoj M Varma, “Detection Limit for Optically Sensing Specific Protein Interactions in Free-solution”, arXiv preprint arXiv:1712.00224, (2017).
  • Praneet Prakash, Manoj Varma,” Trapping/Pinning of colloidal microspheres over glass substrate using surface features”, Scientific reports, (2017).
  • Praneet Prakash, Suman Pahal, Manoj Varma,”Fluorescence Recovery After Photobleaching in Ultrathin Polymer Films”, (2017).
  • Swathi Suran, Manoj M Varma,” Direct Optical Visualization of Water Transport across Polymer Nano-films”, arXiv preprint arXiv:1709.09824, (2017).
  • Suman Pahal, Ruchi Gakhar, Ashok M Raichur, Manoj M Varma, “Polyelectrolyte multilayers for bio-applications: recent advancements”, IET nanobiotechnology, (2017).
  • Swathi Suran, Manoj Varma, “Bright-field Nanoscopy for Measuring Water Transport in Polymer Nano-membranes”, Novel Techniques in Microscopy, (2017).
  • Manoj Varma, “Performance limitations of label-free sensors in molecular diagnosis using complex samples”, Frontiers in Biological Detection: From Nanosensors to Systems VIII, (2016).
  • Manoj Varma, “Modelling refractive index changes due to molecular interactions”, Proc. of SPIE Vol, (2016).
  • Saswati Dana, Manoj M Varma, “Gas-Selective Signal Amplification in Fluctuation-Based Graphene FET Sensors”, IEEE Sensors Journal, (2016).
  • Manoj M Varma, “Article does not explain the origin of free-solution protein interaction signals”, Proceedings of the National Academy of Sciences, (2016).
  • Prashanth R Prasad, Shankar K Selvaraja, Manoj M Varma, “High precision measurement of intensity peak shifts in tunable cascaded microring intensity sensors”, Optics letters, (2016).
  • Manoj M Varma, “Limitations of label-free sensors in serum based molecular diagnostics”, arXiv preprint arXiv:1505.01032, (2015).
  • Manoj Varma,”Apparatus and methods for sensing or imaging using stacked thin films”, (2012).
  • Manoj M Varma, “Polymer thin film structures for ultra-low cost biosensing”, Optik-International Journal for Light and Electron Optics, (2012).
  • Manoj Varma, Ganapathy Krishnamurthi, “Process for extracting periodic features from images by template matching”, (2007).
  • Manoj M Varma, Halina D Inerowicz, Fred E Regnier, David D Nolte, “High-speed label-free detection by spinning-disk micro-interferometry”, Biosensors and Bioelectronics, (2004).
  • Manoj M Varma, David D Nolte, Halina D Inerowicz, Fred E Regnier, “High-speed label-free multi-analyte detection through micro-interferometry”, Proc. of SPIE Vol, (2003)


Issued Patents: 

  • David D. Nolte, Manoj Varma, Fred E. Regnier, Leilei Peng, Multiplexed biological analyzer planar array apparatus and methods , U.S. Pat. No. 7,910,356 (2011).
  • X. Wang, D. D. Nolte, M. Varma, B. Weichel, T. Norwood, F. Sayegh, M. Zhao, System with extended range of molecular sensing through integrated multi-modal data acquisition, U.S. Pat. No. 7,659,968 (2010).
  • David D. Nolte, Manoj Varma, Fred E. Regnier, Laser scanning interferometric surface metrology , U.S. Pat. No. 7,405,831 (2008).
  • David D. Nolte, Fred E. Regnier, Manoj Varma, Bio-Optical Compact-Disk System , U.S. Pat. No. 6,685,885 (2004).

Filed Patents:

  • David D. Nolte, Manoj Varma, Fred E. Regnier, Leilei Peng, Ming Zhao, Differentially encoded biological analyzer planar array apparatus and methods , Pub. App. No. 20070023643, (2007).
  • David D. Nolte, Manoj Varma, Ming Zhao, In-line quadrature and anti-reflection enhanced phase quadrature interferometric detection , Pub. App. No. 20070212257, (2007).

Conference and Seminars

  • Peng L. L., Varma M. M., Nolte D. D., Regnier F. E., “Characterizing printed protein biolayers using adaptive spinning-disk interferometry”, Conference on Lasers & Electro-Optics (CLEO), p. 1763 (2005).
  • Varma, M.M., Nolte, D.D., Inerowicz, H.D., Regnier, F.E., The BioCD: A high-sensitivity spinning-disk interferometer for antigen detection , Conference on Lasers and Electro-Optics (CLEO), Optical Soc. of America, pt. 2, p 3 pp. vol.2 (Selected as a Hot Topic)(2004).
  • Varma, M.M., Nolte, D.D., Inerowicz, H.D., Regnier, F.E., Photonic phase control in a spinning-disk interferometer for high-speed immunoassays , 2003 Conference on Lasers and Electro-Optics Europe (CLEO/Europe 2003) (IEEE Cat. No.03TH8666), p 713, (2003).
  • Varma, M.M., Nolte, D.D., Inerowicz, H.D., Regnier, F.E., Immobilized macromolecule detection through quadrature microdiffraction , Technical Digest. (IEEE Cat. No.02CH37337),v. 1, pt. 1, p 408, (2002).