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Analysis of Integrated Optofluidic Lab-on-a-Chip Sensor Based on Refractive Index and Absorbance Sensing

TitleAnalysis of Integrated Optofluidic Lab-on-a-Chip Sensor Based on Refractive Index and Absorbance Sensing
Publication TypeJournal Article
Year of Publication2013
AuthorsKrishnaswamy, N, Srinivas, T, Rao, GM, Varma, MM
JournalIEEE Sensors Journal
Date PublishedMay
KeywordsAbsorbance, absorbance based sensing, absorbance sensing, fluidic gap, integrated optofluidic lab-on-a-chip sensor, lab-on-a-chip, light absorption, micro-optics, microfluidic channel, mode mismatch, mode-mismatch, optofluidics, refractive index, refractive index measurement, Sensitivity, spot size, waveguide geometry

The analysis of a fully integrated optofluidic lab-on-a-chip sensor is presented in this paper. This device is comprised of collinear input and output waveguides that are separated by a microfluidic channel. When light is passed through the analyte contained in the fluidic gap, optical power loss occurs owing to absorption of light. Apart from absorption, a mode-mismatch between the input and output waveguides occurs when the light propagates through the fluidic gap. The degree of mode-mismatch and quantum of optical power loss due to absorption of light by the fluid form the basis of our analysis. This sensor can detect changes in refractive index and changes in concentration of species contained in the analyte. The sensitivity to detect minute changes depends on many parameters. The parameters that influence the sensitivity of the sensor are mode spot size, refractive index of the fluid, molar concentration of the species contained in the analyte, width of the fluidic gap, and waveguide geometry. By correlating various parameters, an optimal fluidic gap distance corresponding to a particular mode spot size that achieves the best sensitivity is determined both for refractive index and absorbance-based sensing.