Sorry, you need to enable JavaScript to visit this website.
office.cense@iisc.ac.in | +91-80-2293 3276/ +91-80-2293 3291 | Sitemap

Caenorhabditis elegans sensory neurons modulate pathogen specific responses via HLH-30/TFEB transcription factor and FSHR-1 GPCR axes of immunity

TitleCaenorhabditis elegans sensory neurons modulate pathogen specific responses via HLH-30/TFEB transcription factor and FSHR-1 GPCR axes of immunity
Publication TypeJournal Article
Year of Publication2019
AuthorsGupta, A, Varma, M, Singh, V
JournalbioRxiv
Pagination609610
Abstract

Pattern recognition receptors allow animals to sense microbe associated molecular patterns and mount effective immune responses. It is not clear how Caenorhabditis elegans recognizes pathogenic microbes in absence of classical pattern recognition pathways. Here, we asked if sensory neurons of C. elegans allow it to distinguish between pathogens. Exposure of C. elegans to a Gram positive bacterium Enterococcus faecalis or to a Gram negative bacterium Pseudomonas aeruginosa showed predominantly pathogen-specific signatures. Using nematodes defective in sensory perception, we show that neuronal sensing is essential to mount pathogen specific immune response. OSM-6 expressing, ciliated neurons exert non-cell autonomous control of immune effector production via an OSM-6-FSHR-1 GPCR axis as well as an OSM-6-HLH-30/TFEB transcription factor axis during E. faecalis infection. OSM-6-FSHR-1 axis also controls immune response to P. aeruginosa. In all, this study delineates essential role of sensory perception in the regulation of pathogen-specific immunity in C. elegans.

DOI10.1101/609610