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Characterization and performance study of packaged micropump for drug delivery

TitleCharacterization and performance study of packaged micropump for drug delivery
Publication TypeConference Paper
Year of Publication2013
AuthorsKumar, KBV, Nayak, MM, Dinesh, NS, Rajanna, K
Conference Name2013 8th International Microsystems, Packaging, Assembly and Circuits Technology Conference (IMPACT)
Date PublishedOct
KeywordsActuators, bioMEMS, blood pressure, Drug delivery, drug delivery systems, Electron tubes, flexible silicone tube, flow control, flow rate voltage linear dependence, fluid medium flow rate, Fluids, foam fluid medium, gas fluid medium, higher viscosity fluids, liquid fluid medium, microfluidics, microliter fluid flow control, micropump based drug delivery, micropump characterization, micropump performance, micropumps, packaged micropump, pump flow rate, self priming peristaltic pump, single cam mechanism, size 1.5 mm, size 2.5 mm, voltage 2.5 V to 5 V

In this work, we present the characterization and performance studies of self-priming peristaltic pump for drug delivery application. Conventional materials and methods have been used to fabricate single cam mechanism based peristaltic micropump. To control the fluid flow precisely in micro liter range, a single cam mechanism has been used instead of conventional roller mechanism. The fabricated pump is suitable for liquid, gas and foam. Using water as a fluid medium, a flow rate of 12.5 μl/rpm is achieved using a flexible silicone tube of inner diameter 1.5 mm and outer diameter 2.5 mm. Other than water, higher viscosity fluids showed a decrease in the flow rate. The designed micropump exhibits a linear dependence of flow rate in the voltage range of 2.5V to 5V. Drug delivery using micropump demands that the micropump has to pump against the blood pressure (maximum of 25kPa) with constant flow rate. Here the designed pump is able to pump the liquid with a constant flow rate of 500μl/min (water) up to a backpressure of 40kPa. It was observed that, by increasing the backpressure above 40kPa, flow rate of the pump gradually decreased to 125μl/min at 120kPa. In addition, Micropump based drug delivery demands that the micropump should be normally in closed condition in all the positions to avoid drug leakage and bleeding. Hence, micropump has been characterized for normally closed condition in all positions (0° to 360°). However, a minute leak of 0.14 % was found for an inlet pressure of 140kPa. Also, the normally closed region with no leak is observed up to 60kPa of pressure in all positions (0° to 360°).