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Detection of glycated hemoglobin using 3-Aminophenylboronic acid modified graphene oxide

TitleDetection of glycated hemoglobin using 3-Aminophenylboronic acid modified graphene oxide
Publication TypeConference Paper
Year of Publication2011
AuthorsV, SRKrishna, Bhat, N, Amrutur, B, Chakrapani, K, Sampath, S
Conference NameLife Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH
Date PublishedApril
Keywords3-Aminophenylboronic acid, amide linkage, APBA modified graphene oxide, Biosensors, Carbon, Chemicals, Compounds, CxOy, electrochemical detection, electrochemical impedance spectroscopy, electrochemical sensors, Electrodes, glassy carbon electrode, Glycated Hemoglobin, glycated hemoglobin detection, graphene, Graphene Oxide, infrared spectra, IR spectroscopy, proteins, Sensors, Spectroscopy, Sugar
Abstract

This paper presents the chemical synthesis of 3-Aminophenylboronic acid (APBA) modified graphene oxide (GO) and its application to the electrochemical detection of glycated hemoglobin (GHb). The compound (GO-APBA) was synthesized by forming an amide linkage between the amino group (-NH2) of APBA and the carboxylic group (-COOH) of GO. The compound was characterized using IR spectroscopy. Detection of GHb was carried out using Electrochemical Impedance Spectroscopic (EIS) measurements with GO-APBA modified glassy carbon electrode as the working electrode.

DOI10.1109/LISSA.2011.5754140