Development of biosensor for detection of serum creatinine

Serum creatinine is an established biochemical marker for monitoring of renal function. Analytical methods to detect creatinine concentration have been investigated as early as 1886. However, majority of these methods involve sophisticated instrumentation which limits its accessibility to economically challenged patients. In this regard, point of care biosensors provide a low-cost solution coupled with simple instrumentation. There has been growing interest in development of point-of-care technology (POCT) devices for creatinine estimation. However, majority of these POCT devices are enzymatic assays, which add to the complexity and the cost. In this work, we aim to develop non-enzymatic electrochemical creatinine biosensor which simplifies the process of routine clinical analysis, and thereby making it accessible due to its low-cost.